*
|
The remainder of this cover page shall be filled out for a reporting person’s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.
|
CUSIP No. 67552A108
|
Page 2 of 18
|
1.
|
Name of reporting persons
Venrock Healthcare Capital Partners, L.P.
|
|||||
2.
|
Check the appropriate box if a member of a group (see instructions)
(a) x1 (b) ¨
|
|||||
3.
|
SEC use only
|
|||||
4.
|
Citizenship or place of organization
Delaware
|
|||||
Number of
shares
beneficially
owned by
each
reporting
person
with:
|
|
5.
|
|
Sole voting power
0
|
||
|
6.
|
|
Shared voting power
1,885,6682
|
|||
|
7.
|
|
Sole dispositive power
0
|
|||
|
8.
|
|
Shared dispositive power
1,885,6682
|
|||
9.
|
Aggregate amount beneficially owned by each reporting person
1,885,6682
|
|||||
10.
|
Check if the aggregate amount in Row (9) excludes certain shares (see instructions) ¨
|
|||||
11.
|
Percent of class represented by amount in Row (9)
9.1%3
|
|||||
12.
|
Type of reporting person (see instructions)
PN
|
1
|
Venrock Healthcare Capital Partners, L.P., VHCP Co-Investment Holdings, LLC, Venrock Healthcare Capital Partners II, L.P., VHCP Co-Investment Holdings II, LLC, VHCP Management, LLC, VHCP Management II, LLC, Bong Koh and Anders Hove are members of a group for the purposes of this Schedule 13G.
|
2
|
Consists of (i) 792,351 shares of common stock owned by Venrock Healthcare Capital Partners, L.P., including 118,981 shares underlying immediately exercisable warrants; (ii) 144,945 shares of common stock owned by VHCP Co-Investment Holdings, LLC, including 21,765 shares underlying immediately exercisable warrants; (iii) 674,803 shares of common stock owned by Venrock Healthcare Capital Partners II, L.P.; and (iv) 273,569 shares of common stock owned by VHCP Co-Investment Holdings II, LLC.
|
3
|
This percentage is calculated based upon 20,503,211 shares of common stock outstanding as of October 31, 2015, as set forth in Issuer’s Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission on November 5, 2015.
|
CUSIP No. 67552A108
|
Page 3 of 18 |
1.
|
Name of reporting persons
VHCP Co-Investment Holdings, LLC
|
|||||
2.
|
Check the appropriate box if a member of a group (see instructions)
(a) x1 (b) ¨
|
|||||
3.
|
SEC use only
|
|||||
4.
|
Citizenship or place of organization
Delaware
|
|||||
Number of
shares
beneficially
owned by
each
reporting
person
with:
|
|
5.
|
|
Sole voting power
0
|
||
|
6.
|
|
Shared voting power
1,885,6682
|
|||
|
7.
|
|
Sole dispositive power
0
|
|||
|
8.
|
|
Shared dispositive power
1,885,6682
|
|||
9.
|
Aggregate amount beneficially owned by each reporting person
1,885,6682
|
|||||
10.
|
Check if the aggregate amount in Row (9) excludes certain shares (see instructions) ¨
|
|||||
11.
|
Percent of class represented by amount in Row (9)
9.1%3
|
|||||
12.
|
Type of reporting person (see instructions)
OO
|
1
|
Venrock Healthcare Capital Partners, L.P., VHCP Co-Investment Holdings, LLC, Venrock Healthcare Capital Partners II, L.P., VHCP Co-Investment Holdings II, LLC, VHCP Management, LLC, VHCP Management II, LLC, Bong Koh and Anders Hove are members of a group for the purposes of this Schedule 13G.
|
2
|
Consists of (i) 792,351 shares of common stock owned by Venrock Healthcare Capital Partners, L.P., including 118,981 shares underlying immediately exercisable warrants; (ii) 144,945 shares of common stock owned by VHCP Co-Investment Holdings, LLC, including 21,765 shares underlying immediately exercisable warrants; (iii) 674,803 shares of common stock owned by Venrock Healthcare Capital Partners II, L.P.; and (iv) 273,569 shares of common stock owned by VHCP Co-Investment Holdings II, LLC.
|
3
|
This percentage is calculated based upon 20,503,211 shares of common stock outstanding as of October 31, 2015, as set forth in Issuer’s Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission on November 5, 2015.
|
||
CUSIP No. 67552A108
|
Page 4 of 18 |
1.
|
Name of reporting persons
Venrock Healthcare Capital Partners II, L.P.
|
|||||
2.
|
Check the appropriate box if a member of a group (see instructions)
(a) x1 (b) ¨
|
|||||
3.
|
SEC use only
|
|||||
4.
|
Citizenship or place of organization
Delaware
|
|||||
Number of
shares
beneficially
owned by
each
reporting
person
with:
|
|
5.
|
|
Sole voting power
0
|
||
|
6.
|
|
Shared voting power
1,885,6682
|
|||
|
7.
|
|
Sole dispositive power
0
|
|||
|
8.
|
|
Shared dispositive power
1,885,6682
|
|||
9.
|
Aggregate amount beneficially owned by each reporting person
1,885,6682
|
|||||
10.
|
Check if the aggregate amount in Row (9) excludes certain shares (see instructions) ¨
|
|||||
11.
|
Percent of class represented by amount in Row (9)
9.1%3
|
|||||
12.
|
Type of reporting person (see instructions)
PN
|
1
|
Venrock Healthcare Capital Partners, L.P., VHCP Co-Investment Holdings, LLC, Venrock Healthcare Capital Partners II, L.P., VHCP Co-Investment Holdings II, LLC, VHCP Management, LLC, VHCP Management II, LLC, Bong Koh and Anders Hove are members of a group for the purposes of this Schedule 13G.
|
2
|
Consists of (i) 792,351 shares of common stock owned by Venrock Healthcare Capital Partners, L.P., including 118,981 shares underlying immediately exercisable warrants; (ii) 144,945 shares of common stock owned by VHCP Co-Investment Holdings, LLC, including 21,765 shares underlying immediately exercisable warrants; (iii) 674,803 shares of common stock owned by Venrock Healthcare Capital Partners II, L.P.; and (iv) 273,569 shares of common stock owned by VHCP Co-Investment Holdings II, LLC.
|
3
|
This percentage is calculated based upon 20,503,211 shares of common stock outstanding as of October 31, 2015, as set forth in Issuer’s Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission on November 5, 2015.
|
CUSIP No. 67552A108
|
Page 5 of 18 |
1.
|
Name of reporting persons
VHCP Co-Investment Holdings II, LLC
|
|||||
2.
|
Check the appropriate box if a member of a group (see instructions)
(a) x1 (b) ¨
|
|||||
3.
|
SEC use only
|
|||||
4.
|
Citizenship or place of organization
Delaware
|
|||||
Number of
shares
beneficially
owned by
each
reporting
person
with:
|
|
5.
|
|
Sole voting power
0
|
||
|
6.
|
|
Shared voting power
1,885,6682
|
|||
|
7.
|
|
Sole dispositive power
0
|
|||
|
8.
|
|
Shared dispositive power
1,885,6682
|
|||
9.
|
Aggregate amount beneficially owned by each reporting person
1,885,6682
|
|||||
10.
|
Check if the aggregate amount in Row (9) excludes certain shares (see instructions) ¨
|
|||||
11.
|
Percent of class represented by amount in Row (9)
9.1%3
|
|||||
12.
|
Type of reporting person (see instructions)
OO
|
1
|
Venrock Healthcare Capital Partners, L.P., VHCP Co-Investment Holdings, LLC, Venrock Healthcare Capital Partners II, L.P., VHCP Co-Investment Holdings II, LLC, VHCP Management, LLC, VHCP Management II, LLC, Bong Koh and Anders Hove are members of a group for the purposes of this Schedule 13G.
|
2
|
Consists of (i) 792,351 shares of common stock owned by Venrock Healthcare Capital Partners, L.P., including 118,981 shares underlying immediately exercisable warrants; (ii) 144,945 shares of common stock owned by VHCP Co-Investment Holdings, LLC, including 21,765 shares underlying immediately exercisable warrants; (iii) 674,803 shares of common stock owned by Venrock Healthcare Capital Partners II, L.P.; and (iv) 273,569 shares of common stock owned by VHCP Co-Investment Holdings II, LLC.
|
3
|
This percentage is calculated based upon 20,503,211 shares of common stock outstanding as of October 31, 2015, as set forth in Issuer’s Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission on November 5, 2015.
|
CUSIP No. 67552A108
|
Page 6 of 18 |
1.
|
Name of reporting persons
VHCP Management, LLC
|
|||||
2.
|
Check the appropriate box if a member of a group (see instructions)
(a) x1 (b) ¨
|
|||||
3.
|
SEC use only
|
|||||
4.
|
Citizenship or place of organization
Delaware
|
|||||
Number of
shares
beneficially
owned by
each
reporting
person
with:
|
|
5.
|
|
Sole voting power
0
|
||
|
6.
|
|
Shared voting power
1,885,6682
|
|||
|
7.
|
|
Sole dispositive power
0
|
|||
|
8.
|
|
Shared dispositive power
1,885,6682
|
|||
9.
|
Aggregate amount beneficially owned by each reporting person
1,885,6682
|
|||||
10.
|
Check if the aggregate amount in Row (9) excludes certain shares (see instructions) ¨
|
|||||
11.
|
Percent of class represented by amount in Row (9)
9.1%3
|
|||||
12.
|
Type of reporting person (see instructions)
OO
|
1
|
Venrock Healthcare Capital Partners, L.P., VHCP Co-Investment Holdings, LLC, Venrock Healthcare Capital Partners II, L.P., VHCP Co-Investment Holdings II, LLC, VHCP Management, LLC, VHCP Management II, LLC, Bong Koh and Anders Hove are members of a group for the purposes of this Schedule 13G.
|
2
|
Consists of (i) 792,351 shares of common stock owned by Venrock Healthcare Capital Partners, L.P., including 118,981 shares underlying immediately exercisable warrants; (ii) 144,945 shares of common stock owned by VHCP Co-Investment Holdings, LLC, including 21,765 shares underlying immediately exercisable warrants; (iii) 674,803 shares of common stock owned by Venrock Healthcare Capital Partners II, L.P.; and (iv) 273,569 shares of common stock owned by VHCP Co-Investment Holdings II, LLC.
|
3
|
This percentage is calculated based upon 20,503,211 shares of common stock outstanding as of October 31, 2015, as set forth in Issuer’s Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission on November 5, 2015.
|
CUSIP No. 67552A108
|
Page 7 of 18 |
1.
|
Name of reporting persons
VHCP Management II, LLC
|
|||||
2.
|
Check the appropriate box if a member of a group (see instructions)
(a) x1 (b) ¨
|
|||||
3.
|
SEC use only
|
|||||
4.
|
Citizenship or place of organization
Delaware
|
|||||
Number of
shares
beneficially
owned by
each
reporting
person
with:
|
|
5.
|
|
Sole voting power
0
|
||
|
6.
|
|
Shared voting power
1,885,6682
|
|||
|
7.
|
|
Sole dispositive power
0
|
|||
|
8.
|
|
Shared dispositive power
1,885,6682
|
|||
9.
|
Aggregate amount beneficially owned by each reporting person
1,885,6682
|
|||||
10.
|
Check if the aggregate amount in Row (9) excludes certain shares (see instructions) ¨
|
|||||
11.
|
Percent of class represented by amount in Row (9)
9.1%3
|
|||||
12.
|
Type of reporting person (see instructions)
OO
|
1
|
Venrock Healthcare Capital Partners, L.P., VHCP Co-Investment Holdings, LLC, Venrock Healthcare Capital Partners II, L.P., VHCP Co-Investment Holdings II, LLC, VHCP Management, LLC, VHCP Management II, LLC, Bong Koh and Anders Hove are members of a group for the purposes of this Schedule 13G.
|
2
|
Consists of (i) 792,351 shares of common stock owned by Venrock Healthcare Capital Partners, L.P., including 118,981 shares underlying immediately exercisable warrants; (ii) 144,945 shares of common stock owned by VHCP Co-Investment Holdings, LLC, including 21,765 shares underlying immediately exercisable warrants; (iii) 674,803 shares of common stock owned by Venrock Healthcare Capital Partners II, L.P.; and (iv) 273,569 shares of common stock owned by VHCP Co-Investment Holdings II, LLC.
|
3
|
This percentage is calculated based upon 20,503,211 shares of common stock outstanding as of October 31, 2015, as set forth in Issuer’s Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission on November 5, 2015.
|
CUSIP No. 67552A108
|
Page 8 of 18 |
1.
|
Name of reporting persons
Hove, Anders
|
|||||
2.
|
Check the appropriate box if a member of a group (see instructions)
(a) x1 (b) ¨
|
|||||
3.
|
SEC use only
|
|||||
4.
|
Citizenship or place of organization
United States
|
|||||
Number of
shares
beneficially
owned by
each
reporting
person
with:
|
|
5.
|
|
Sole voting power
0
|
||
|
6.
|
|
Shared voting power
1,885,6682
|
|||
|
7.
|
|
Sole dispositive power
0
|
|||
|
8.
|
|
Shared dispositive power
1,885,6682
|
|||
9.
|
Aggregate amount beneficially owned by each reporting person
1,885,6682
|
|||||
10.
|
Check if the aggregate amount in Row (9) excludes certain shares (see instructions) ¨
|
|||||
11.
|
Percent of class represented by amount in Row (9)
9.1%3
|
|||||
12.
|
Type of reporting person (see instructions)
IN
|
1
|
Venrock Healthcare Capital Partners, L.P., VHCP Co-Investment Holdings, LLC, Venrock Healthcare Capital Partners II, L.P., VHCP Co-Investment Holdings II, LLC, VHCP Management, LLC, VHCP Management II, LLC, Bong Koh and Anders Hove are members of a group for the purposes of this Schedule 13G.
|
2
|
Consists of (i) 792,351 shares of common stock owned by Venrock Healthcare Capital Partners, L.P., including 118,981 shares underlying immediately exercisable warrants; (ii) 144,945 shares of common stock owned by VHCP Co-Investment Holdings, LLC, including 21,765 shares underlying immediately exercisable warrants; (iii) 674,803 shares of common stock owned by Venrock Healthcare Capital Partners II, L.P.; and (iv) 273,569 shares of common stock owned by VHCP Co-Investment Holdings II, LLC.
|
3
|
This percentage is calculated based upon 20,503,211 shares of common stock outstanding as of October 31, 2015, as set forth in Issuer’s Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission on November 5, 2015.
|
CUSIP No. 67552A108
|
Page 9 of 18 |
1.
|
Name of reporting persons
Koh, Bong
|
|||||
2.
|
Check the appropriate box if a member of a group (see instructions)
(a) x1 (b) ¨
|
|||||
3.
|
SEC use only
|
|||||
4.
|
Citizenship or place of organization
United States
|
|||||
Number of
shares
beneficially
owned by
each
reporting
person
with:
|
|
5.
|
|
Sole voting power
0
|
||
|
6.
|
|
Shared voting power
1,885,6682
|
|||
|
7.
|
|
Sole dispositive power
0
|
|||
|
8.
|
|
Shared dispositive power
1,885,6682
|
|||
9.
|
Aggregate amount beneficially owned by each reporting person
1,885,6682
|
|||||
10.
|
Check if the aggregate amount in Row (9) excludes certain shares (see instructions) ¨
|
|||||
11.
|
Percent of class represented by amount in Row (9)
9.1%3
|
|||||
12.
|
Type of reporting person (see instructions)
IN
|
1
|
Venrock Healthcare Capital Partners, L.P., VHCP Co-Investment Holdings, LLC, Venrock Healthcare Capital Partners II, L.P., VHCP Co-Investment Holdings II, LLC, VHCP Management, LLC, VHCP Management II, LLC, Bong Koh and Anders Hove are members of a group for the purposes of this Schedule 13G.
|
2
|
Consists of (i) 792,351 shares of common stock owned by Venrock Healthcare Capital Partners, L.P., including 118,981 shares underlying immediately exercisable warrants; (ii) 144,945 shares of common stock owned by VHCP Co-Investment Holdings, LLC, including 21,765 shares underlying immediately exercisable warrants; (iii) 674,803 shares of common stock owned by Venrock Healthcare Capital Partners II, L.P.; and (iv) 273,569 shares of common stock owned by VHCP Co-Investment Holdings II, LLC.
|
3
|
This percentage is calculated based upon 20,503,211 shares of common stock outstanding as of October 31, 2015, as set forth in Issuer’s Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission on November 5, 2015.
|
CUSIP No. 67552A108
|
Page 10 of 18 |
(a)
|
Name of Issuer
|
(b)
|
Address of Issuer’s Principal Executive Offices
|
(a)
|
Name of Person Filing
|
(b)
|
Address of Principal Business Office or, if none, Residence
|
New York Office:
|
Palo Alto Office:
|
Boston Office:
|
||
530 Fifth Avenue
|
3340 Hillview Avenue
|
470 Atlantic Avenue
|
||
22nd Floor
|
Palo Alto, CA 94304
|
4th Floor
|
||
New York, NY 10036
|
Boston, MA 02210
|
(c)
|
Citizenship
|
(d)
|
Title of Class of Securities
|
(e)
|
CUSIP Number
|
Item 3.
|
If this statement is filed pursuant to §§240.13d-1(b), or 240.13d-2(b) or (c), check whether the person filing is a:
|
CUSIP No. 67552A108
|
Page 11 of 18 |
Item 4.
|
Ownership
|
(a)
|
Amount Beneficially Owned as of March 3, 2016:
|
Venrock Healthcare Capital Partners, L.P.
|
1,885,668
|
(1)
|
||
VHCP Co-Investment Holdings, LLC
|
1,885,668
|
(1)
|
||
Venrock Healthcare Capital Partners II, L.P.
|
1,885,668
|
(1)
|
||
VHCP Co-Investment Holdings II, LLC
|
1,885,668
|
(1)
|
||
VHCP Management, LLC
|
1,885,668
|
(1)
|
||
VHCP Management II, LLC
|
1,885,668
|
(1)
|
||
Anders Hove
|
1,885,668
|
(1)
|
||
Bong Koh
|
1,885,668
|
(1)
|
(b)
|
Percent of Class as of March 3, 2016:
|
Venrock Healthcare Capital Partners, L.P.
|
9.1
|
%
|
||||
VHCP Co-Investment Holdings, LLC
|
9.1
|
%
|
||||
Venrock Healthcare Capital Partners II, L.P.
|
9.1
|
%
|
||||
VHCP Co-Investment Holdings II, LLC
|
9.1
|
%
|
||||
VHCP Management, LLC
|
9.1
|
%
|
||||
VHCP Management II, LLC
|
9.1
|
%
|
||||
Anders Hove
|
9.1
|
%
|
||||
Bong Koh
|
9.1
|
%
|
||||
(c)
|
Number of shares as to which the person has, as of March 3, 2016:
|
(i)
|
Sole power to vote or to direct the vote
|
Venrock Healthcare Capital Partners, L.P.
|
0
|
|
||
VHCP Co-Investment Holdings, LLC
|
0
|
|
||
Venrock Healthcare Capital Partners II, L.P.
|
0
|
|
||
VHCP Co-Investment Holdings II, LLC
|
0
|
|
||
VHCP Management, LLC
|
0
|
|
||
VHCP Management II, LLC
|
0
|
|
||
Anders Hove
|
0
|
|
||
Bong Koh
|
0
|
|
(ii)
|
Shared power to vote or to direct the vote
|
Venrock Healthcare Capital Partners, L.P.
|
1,885,668
|
(1)
|
||
VHCP Co-Investment Holdings, LLC
|
1,885,668
|
(1)
|
||
Venrock Healthcare Capital Partners II, L.P.
|
1,885,668
|
(1)
|
||
VHCP Co-Investment Holdings II, LLC
|
1,885,668
|
(1)
|
||
VHCP Management, LLC
|
1,885,668
|
(1)
|
||
VHCP Management II, LLC
|
1,885,668
|
(1)
|
||
Anders Hove
|
1,885,668
|
(1)
|
||
Bong Koh
|
1,885,668
|
(1)
|
CUSIP No. 67552A108
|
Page 12 of 18 |
(iii)
|
Sole power to dispose or to direct the disposition of
|
Venrock Healthcare Capital Partners, L.P.
|
0
|
|
||
VHCP Co-Investment Holdings, LLC
|
0
|
|
||
Venrock Healthcare Capital Partners II, L.P.
|
0
|
|
||
VHCP Co-Investment Holdings II, LLC
|
0
|
|
||
VHCP Management, LLC
|
0
|
|
||
VHCP Management II, LLC
|
0
|
|
||
Anders Hove
|
0
|
|
||
Bong Koh
|
0
|
|
(iv)
|
Shared power to dispose or to direct the disposition of
|
Venrock Healthcare Capital Partners, L.P.
|
1,885,668
|
(1)
|
||
VHCP Co-Investment Holdings, LLC
|
1,885,668
|
(1)
|
||
Venrock Healthcare Capital Partners II, L.P.
|
1,885,668
|
(1)
|
||
VHCP Co-Investment Holdings II, LLC
|
1,885,668
|
(1)
|
||
VHCP Management, LLC
|
1,885,668
|
(1)
|
||
VHCP Management II, LLC
|
1,885,668
|
(1)
|
||
Anders Hove
|
1,885,668
|
(1)
|
||
Bong Koh
|
1,885,668
|
(1)
|
(1)
|
These shares are owned directly as follows: (i) 792,351 shares of common stock are owned by VHCP, including 118,981 shares underlying immediately exercisable warrants; (ii) 144,945 shares of common stock are owned by VHCP Co-Investment, including 21,765 shares underlying immediately exercisable warrants; (iii) 674,803 shares of common stock are owned by VHCP II; and (iv) 273,569 shares of common stock are owned by VHCP Co-Investment II. VHCP Management is the general partner of VHCP and the manager of VHCP Co-Investment. VHCP Management II is the general partner of VHCP II and the manager of VHCP Co-Investment II. Messrs. Hove and Koh are the managing members of VHCP Management and VHCP Management II.
|
Item 5.
|
Ownership of Five Percent or Less of a Class
|
Item 6.
|
Ownership of More than Five Percent on Behalf of Another Person
|
Item 7.
|
Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on By the Parent Holding Company or Control Person.
|
Item 8.
|
Identification and Classification of Members of the Group
|
CUSIP No. 67552A108
|
Page 13 of 18 |
Item 9.
|
Notice of Dissolution of a Group
|
Item 10.
|
Certification
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Venrock Healthcare Capital Partners, L.P.
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VHCP Co-Investment Holdings, LLC
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By:
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VHCP Management, LLC,
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By:
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VHCP Management, LLC,
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its General Partner
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its Manager
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By:
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/s/ David L. Stepp
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By:
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/s/ David L. Stepp
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Name:
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David L. Stepp
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Name:
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David L. Stepp
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Title:
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Authorized Signatory
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Title:
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Authorized Signatory
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VHCP Management, LLC
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By:
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/s/ David L. Stepp
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Name:
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David L. Stepp
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Title:
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Authorized Signatory
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/s/ David L. Stepp, as attorney-in-fact
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Anders Hove
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/s/ David L. Stepp, as attorney-in-fact
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Bong Koh
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Venrock Healthcare Capital Partners II, L.P.
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VHCP Co-Investment Holdings II, LLC
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By:
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VHCP Management II, LLC,
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By:
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VHCP Management II, LLC,
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its General Partner
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its Manager
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By:
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/s/ David L. Stepp
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By:
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/s/ David L. Stepp
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Name:
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David L. Stepp
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Name:
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David L. Stepp
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Title:
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Authorized Signatory
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Title:
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Authorized Signatory
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VHCP Management II, LLC
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By:
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/s/ David L. Stepp
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Name:
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David L. Stepp
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Title:
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Authorized Signatory
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A:
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Joint Filing Agreement
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B:
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Power of Attorney for Anders Hove
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C:
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Power of Attorney for Bong Koh
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Venrock Healthcare Capital Partners, L.P.
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VHCP Co-Investment Holdings, LLC
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By:
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VHCP Management, LLC,
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By:
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VHCP Management, LLC,
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|||||||||
its General Partner
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its Manager
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|||||||||||
By:
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/s/ David L. Stepp
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By:
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/s/ David L. Stepp
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|||||||||
Name:
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David L. Stepp
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Name:
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David L. Stepp
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|||||||||
Title:
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Authorized Signatory
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Title:
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Authorized Signatory
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|||||||||
VHCP Management, LLC
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||||||||||||
By:
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/s/ David L. Stepp
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|||||||||||
Name:
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David L. Stepp
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|||||||||||
Title:
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Authorized Signatory
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|||||||||||
/s/ David L. Stepp, as attorney-in-fact
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||||||||||||
Anders Hove
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||||||||||||
/s/ David L. Stepp, as attorney-in-fact
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||||||||||||
Bong Koh
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Venrock Healthcare Capital Partners II, L.P.
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VHCP Co-Investment Holdings II, LLC
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|||||||||||
By:
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VHCP Management II, LLC,
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By:
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VHCP Management II, LLC,
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|||||||||
its General Partner
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its Manager
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|||||||||||
By:
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/s/ David L. Stepp
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By:
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/s/ David L. Stepp
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|||||||||
Name:
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David L. Stepp
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Name:
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David L. Stepp
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|||||||||
Title:
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Authorized Signatory
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Title:
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Authorized Signatory
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|||||||||
VHCP Management II, LLC
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||||||||||||
By:
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/s/ David L. Stepp
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|||||||||||
Name:
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David L. Stepp
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Title:
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Authorized Signatory
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(i)
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prepare execute and file, for and on behalf of the undersigned, any and all documents and filings that are required or advisable to be made with the United States Securities and Exchange Commission, any stock exchange or similar authority, under the Securities Exchange Act of 1934, as amended (the “Exchange Act”), and the rules and regulations promulgated thereunder, including without limitation (a) any Joint Filing Agreement under Rule 13d-1(k) of the Exchange Act (or any successor provision thereunder), Schedule 13D and Schedule 13G (or any successor schedules or forms adopted under the Exchange Act ) and any amendments thereto in accordance with Section 13 of the Exchange Act and the rules thereunder, and (b) Forms 3, 4 and 5 and any amendments thereto in accordance with Section 16(a) of the Exchange Act and the rules thereunder; and
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(ii)
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take any other action of any nature whatsoever in connection with the foregoing which, in the opinion of such attorney-in-fact, may be of benefit, in the best interest of, or legally required by, the undersigned, it being understood that the documents executed by such attorney-in-fact on behalf of the undersigned pursuant to this Power of Attorney shall be in such form and shall contain such terms and conditions as such attorney-in-fact may approve in such attorney-in-fact’s discretion.
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/s/ Anders Hove
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(i)
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prepare, execute and file, for and on behalf of the undersigned, any and all documents and filings that are required or advisable to be made with the United States Securities and Exchange Commission, any stock exchange or similar authority, under the Securities Exchange Act of 1934, as amended (the “Exchange Act”), and the rules and regulations promulgated thereunder, including without limitation (a) any Joint Filing Agreement under Rule 13d-1(k) of the Exchange Act (or any successor provision thereunder), Schedule 13D and Schedule 13G (or any successor schedules or forms adopted under the Exchange Act) and any amendments thereto in accordance with Section 13 of the Exchange Act and the rules thereunder, and (b) Forms 3, 4 and 5 and any amendments thereto in accordance with Section 16(a) of the Exchange Act and the rules thereunder; and
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(ii)
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take any other action of any nature whatsoever in connection with the foregoing which, in the opinion of such attorney-in-fact, may be of benefit, in the best interest of, or legally required by, the undersigned, it being understood that the documents executed by such attorney-in-fact on behalf of the undersigned pursuant to this Power of Attorney shall be in such form and shall contain such terms and conditions as such attorney-in-fact may approve in such attorney-in-fact’s discretion.
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/s/ Bong Koh
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Bong Koh
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